منابع مشابه
Diabetes as a stress response
Diabetes as a stress response he origin of adult-onset diabetes may be a counterproductive stress reaction in the endoplasmic reticulum (ER), according to Umut Özcan, Gökhan Hotamisligil (Harvard School of Public Health, Boston, MA), and colleagues. Type II or adult-onset diabetes has remained a mystery because the body seemingly acts against its own interests. As caloric intake and obesity ris...
متن کاملBinary Regression With a Misclassified Response Variable in Diabetes Data
Objectives: The categorical data analysis is very important in statistics and medical sciences. When the binary response variable is misclassified, the results of fitting the model will be biased in estimating adjusted odds ratios. The present study aimed to use a method to detect and correct misclassification error in the response variable of Type 2 Diabetes Mellitus (T2DM), applying binary ...
متن کاملOxidative Stress as a Covariate of Recovery in Diabetes Therapy
Excess glucose – hyperglycemia – has long been associated with type 2 diabetes. Ancient literature from Egypt and India describe the disease; it was easily identifiable because “a patient’s urine attracted ants” (1). More than two millennia later, monitoring glycemic status continues to be central to clinical management. It is currently the only variable accepted for standardization of both dia...
متن کاملEmotional stress as a cause of diabetes mellitus.
from the correlations occupy the final six pages. Little more is said of diabetic acidosis than that insulin administration is indicated to overcome the enzymatic defect produced by ketone formation. The authors' visualization of vomiting in diabetic acidosis as a homeostatic mechanism for the elimination of hydrogen ions is to be deplored. Tables, several with irrelevant and overly complex dat...
متن کاملCellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress
Oxidative stress has been implicated in diabetes long-term complications. In this paper, we summarize the growing evidence suggesting that hyperglycemia-induced overproduction of superoxide by mitochondrial electron transport chain triggers a maladaptive response by affecting several metabolic and signaling pathways involved in the pathophysiology of cellular dysfunction and diabetic complicati...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2004
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1673rr4